![]() That hidden gem someone is raving about today can be unceremoniously removed from all platforms faster than one can ask, “Who is David Zaslav?” So, with the state of media distribution looking more uncertain than ever before, it’s time to build a new canon of midnight movies that are worth preserving. But as we’ve learned over the past year, anything that streaming libraries give us can be just as easily taken away. On the one hand, it’s never been easier to access a litany of pop cultural oddities. The rise of streaming has been a mixed bag for cinephiles who like to get weird. From boundary-pushing new works to insane misfires of yesteryear, IndieWire After Dark is an ongoing reminder that, yes, there is still something out there that you haven’t seen. ET, we take a feature-length beat to discuss an unapologetically bold movie that we fear is falling through the cracks in the age of streaming. ![]() Our weekly column exploring the funkiest fringe cinema is for anyone who can’t bring themselves to sit through one more midnight screening of “Rocky Horror.” Every Friday night at 11:59 p.m. What do a pregnant Arnold Schwarzenegger, a pansexual soccer himbo, a horny orangutan (with a dubious grasp on consent), and an impeccably dressed mean girl played by Rose McGowan have in common? In addition to being our dream blunt rotation, they’re the kinds of cinematic heroes you’ll only find at IndieWire After Dark.
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![]() It’s a fandom that at times matches the mania of the Lost and Game Of Thrones communities at their peaks. More than a few are 20-somethings who grew up with the series, attracted by the combination of Disney animation and easily accessible combat. It has cultivated a dedicated fanbase over the years, encompassing a broad cross-section of Disney fans, anime fans, and those who just enjoy seeing Final Fantasy VII’s Cloud Strife battling Sephiroth in Hercules’ Coliseum. If director Tetsuya Nomura has a bit of a reputation in RPG circles, it’s because Kingdom Hearts absolutely glories in every Nomura cliche imaginable: nonsensical naming conventions, wild psychodrama, and belts, belts, belts ( and zippers). Excitement because Mickey, Donald, and Goofy in 4K is pretty neat bemused laughter because Kingdom Hearts is just that weird. It’s a release that’s apt to inspire equal parts excitement and bemused laughter among PC fans. It was a period when a company like Square might think, “Disney would gladly let us put their best characters in our games.” Legend has it that started as a literal elevator pitch, with a chance meeting between Square Enix producer Shinji Hashimoto and a Disney executive sowing the seeds for a crossover series that would span two decades and nearly a dozen entries, and next week is coming to PC for the first time. It was conceived in 2000, in what was arguably the apex of the company’s influence. Kingdom Hearts straddles two eras in Square Enix history. This is The Limit Break, a fortnightly column in which Kat Bailey explores all things RPG. ![]() ![]() It’s a hard line to balance – how to add professional features without compromising ease of use – but with consistently good updates, its makers, Image-Line, seem to have walked that tightrope. However, like all DAWs, it has become something of a production powerhouse over the years, yet tried to keep that simplistic ethos that won it so many fans at the start. It’s always been ’the easy sequencer’ to make tunes on quickly – too quickly according to some of its early detractors. Most recently I’ve looked at the latest versions of Cubase and Reason – two very different beasts but the absolute pinnacles of their years of development – as well as newish kids on the block like Mixcraft and Tracktion (and very nice they are too).įL Studio is a two-decade old piece of software that also seems to have won the hearts and minds of much of the music production community, especially Stateside.Īs we’ll see later, FL Studio started almost as a game – many of its early adopters certainly produced on it rather like they were playing a video game. We’ve said it before and we’ll say it again: there’s never been a better time to hop on board the music production wagon, especially in terms of the sheer number and variety of DAWs out there. Use FL Studio as a VST plug-in or with ReWire.Can resize and rearrange the user interface.Supports VST standards 1, 2 and 3 for more plug-ins.Multi-track audio recording, time-stretching, pitch shifting audio editing.Mac and PC DAW with super-slick interface for easy song creation.Mastering tools like multiband compression/limiting and parametric EQ are included as well.Price €89 for Fruity | €189 for Producer Contact Image-Line FL Studio 20 key features: A range of effects are already included right in the box to inspire your creativity and put the polish on your mixes - you’ll enjoy giving your tracks everything from delay, distortion, EQ, filtering, phasing, flanging, chorus, vocoding, and reverb. Plus, each track can include up to eight effects and can be routed to any of the other audio tracks. ![]() ![]() At Sweetwater, we’re impressed by the quality of FL Studio’s built-in instruments - they give you a lot of great sounds to work with!įull-featured MIDI music production environmentįL Studio’s flexible loop-creation tools let you beat-slice, time-stretch, chop, and edit your audio. And whether you’re looking for traditional instrumentation or electronic excitement, FL Studio’s powerful browser makes it easy to search sounds by category. Right inside the box, you get 11 virtual synthesizers, giving you great-sounding acoustic/synth bass, electric guitar and plucked strings, sampler tools including a piano, beat-slicing, and tons more. With FL Studio 20 Fruity Edition, you can make virtually any sound. And - for the first time - you can run FL Studio on your Mac with full VST and AU support! You’ll also enjoy a refined Graph Editor, “Legacy” Precomputed FX, an upgraded Channel Sampler, and a bevy of new and updated plug-ins. Plug-in delay compensation ensures a smooth mixing experience. Create with multiple arrangements, each with their complete layouts of automation and pattern clips. Take the load off of your computer with in-situ rendering (freezing). Benefit from support for time signatures, along with unlimited time signature changes. To celebrate the 20th anniversary of FL Studio, Image Line has skipped versions 13-19 and gone straight to 20. For loop building, editing, and mixing, FL Studio is an innovative music-making tool.Īn impressive array of powerful new features Use third-party VSTs to bolster its already impressive selection of built-in plug-ins. Benefit from a super-fast workflow, thanks to FL Studio’s Browser. Beyond that, its flexible Playlist allows you to use Automation and Note data in any combination. Its feature-packed Piano Roll makes arranging and sequencing a breeze. This production software’s Mixer includes effects chains, audio sends, sidechain control, advanced automation, multi-touch support, and more. Image Line FL Studio 20 Fruity Edition is a full-featured melody and loop creation environment. ![]() ![]() Make sure you aren’t accidentally using more than one font! Highlight all your text and select the font you’ve chosen.Ģ. Be sure they are large files so that they won’t print out pixelated.ġ. Use Insert to add images, charts, graphics, etc.Ī. You should have your text all ready in a separate word document – cut and paste from that into your poster.ģ. Look at the many other academic posters on display – what works? What doesn’t?ġ. You can add the Earlham College logo or the seal of the College – download them from the Design Elements tab and then Insert them.ģ. Don’t use too many colors, but use some!Ģ. ![]() You can change the background of your entire poster (Format, Slide Background) or of the inside of the text boxes (Click on the box, Right-click, Format Shape). Text boxes expand and contract based on how much text they hold, so you may have to edit your text or be flexible with your structure.ġ. ![]() You might not fill all these boxes with text, but that’s ok.Ĥ. You will likely need three columns – they can be of equal size OR one wider column in the middle, two slightly more narrow outside columns.Ģ. Under View, try turning on the ruler, dynamic guidelines, static guidelines, or gridlines.ġ. Optional – turn a few things on to make lining things up easier. Remember, you pay for poster printing by the size.Ĥ. One side must be 42 inches, the size of the plotter paperĭ. Change the size of the slide to poster-appropriate using Page SetupĪ. Change the Layout to “Blank” (no text boxes etc)ģ. Open Powerpoint, Create a new (white) slideĢ. If you want to know more about how to export a PowerPoint presentation as a PDF file, you can read the tutorial you can find at Slidesgo School.Īs you have seen, creating a poster in PowerPoint is very easy.Start from scratch OR Choose a template and skip to “Fill in your Template”ġ. From the Options tab, you can set whether to export the whole presentation, a selection of specific slides, or the current slide, in addition to other available options.Save the file with the name of your choice and select Publish. Click File > Export > Create PDF/ XPS Document. If you want to print your final design, you will need to export it to PDF.In the following example, we have adapted the slide to the A4 landscape format. For this, just follow the first step, but instead of opening a new PowerPoint presentation, open an existing one. Another possibility, in addition to using a template with A3 or A4 format already defined, is to adapt a template in 16:9 format.However, if you need a more professional design, at Slidesgo we have plenty of them, even with formats such as A3 and A4 already defined. whatever you want your poster to include. You can change the style of the presentation, add images, texts. Then, the editing possibilities are very numerous.When you click OK, the slide will appear in the new format. In addition, you can choose the orientation of the slides, between portrait and landscape. In the example, we have chosen an A3 paper. In the pop-up window that appears, you can customize or choose the size you need. To do this, click on Design > Slide Size. The first step to creating your poster is to adjust the size in PowerPoint. ![]() ![]() The location, the staff, the activities! There're none better in Maui! We have been guests of this property since it opened in 2009. On the in-room dining menu, I highly recommend the half-baked chocolate cupcake and the surfing goat cheese cake (but the healthier food is GREAT, too!) From Cane & Canoe, the Lobster Bisque, Hamachi Poke, and the Calamari "Chow Fun" are phenomenal - a little party for your taste buds(!). Since the Montage took over, ALL dining experiences, from room service, to Cane & Canoe (signature restaurant & bar), to the Sunset Patio have been elevated to five-star status. Nicole contacted us prior to our arrival with a host of options for dining, activities and excursions, then arranged for all of our requests, down to the last detail. ![]() They are all so friendly, professional and efficient with reservations. We would like to especially highlight Nicole, Janet, Ted, Ayami, Jeramiah, Scott and Dennis. The Concierge team at the Montage are a wealth of information, so helpful and an absolute pleasure to work with. Where to begin? Kapalua Bay is stunning and activities abound: golfing on the Plantation (PGA tour) and Bay courses, surfing, paddle boarding, kayaking, scuba diving, snorkeling, whale watching (seasonal) hiking, tennis, horseback riding, parasailing, the list just goes on and on. The advent of the Montage taking over the property in June elevated the experience to an entirely different level. These observations form the basis of an important subject of investigation, regarding the effects of Gram-negative bacteria on cancer development. Further, postoperative pneumonias are a common complication of thoracic surgery and predominantly caused by Gram-negative bacteria ( 14- 16). Further studies pinpoint Gram-negative bacteria as the most frequent pathogen that led to increased mortality in NSCLC patients ( 12, 13). Pulmonary infections are very common and predict poor prognosis of NSCLC patients ( 11). Further studies on critical influential factors involved in outgrowth and metastasis of NSCLC cells, especially those focused on cancer cells from clinical patients, are urgently needed. Thus, current clinical therapeutic options for NSCLC patients are still limited and their prognoses remain far from acceptable ( 8- 10). However, patients who respond to targeted therapeutics first are frequently and quickly encountered with drug resistance. Recently, personalized treatment of NSCLC patients using targeted therapeutics, which are dominantly based on patients’ and tumors’ precise genetic defects, served as a promising direction for NSCLC clinical management ( 5- 7). In NSCLC patients, general outcomes of standard therapy including surgery, radiation therapy and chemotherapy are poor ( 3, 4). Non-small cell lung cancer (NSCLC) is the most common type and accounts for about 85% of all cases in patients with lung cancer ( 3). Lung cancer is the leading cause of cancer-related death worldwide, with an increasing incidence every year ( 1, 2). Keywords: Lung cancer Gram-negative bacteria lipid synthesis TLR4 TLR9 These findings reveal a new mechanism for pulmonary infection-trigged caner development and provide clues for exploring therapeutics for lung cancer patients. In lung cancer patients, higher expressions of innate immune receptors, TLR4 and TLR9, were observed in those with Gram-negative infections and associated with the aberrant lipid synthesis that was observed in vitro.Ĭonclusions: Pulmonary infections with Gram-negative bacteria lead to aberrant lipid synthesis through TLR4 and TLR9 signaling in lung cancer patients and result in rapid proliferation and metastasis of lung cancer cells. Interference with lipid synthesis efficiently abrogated Gram-negative-bacteria-induced lung cancer development. Knockdown of TLR4 and/or TLR9 was able to block Gram-negative bacteria mediated lipid synthesis and lung cancer development. Mechanistically, Gram-negative bacteria activate TLR4 and TLR9 signaling and enhance lipid synthesis in human lung cancer cells. Results: Gram-negative bacteria significantly promoted lung cancer development including growth and metastasis in dose dependent manner. Knockdown of TLR4 and TLR9 signaling was achieved by transfection with specific shRNAs and administration of specific antagonists. Block lipid synthesis was performed with C75 as a FAS inhibitor and transfection with ACC1 siRNA. Lipid synthesis was evidenced by expressions of FASN and ACC1, as well as BODIPY Fluorophores staining. Tumor growth and metastasis in vivo was evaluated in BALB/c nude mice. ![]() Tumor outgrowth and invasion in vitro was analyzed with MTT assay and Biocoat Matrigel Invasion Chamber. ![]() Methods: Lung cancer cells were isolated from clinical surgical tissues. Herein, we investigated the effect of the co-presence of Gram-negative bacteria on outgrowth and metastasis of lung cancer cells in clinical patients. Patients with lung cancer are very frequently present with pulmonary infections, in particular with Gram-negative bacteria. Interviews with Outstanding Guest Editorsīackground: Lung cancer is the leading cause of cancer-related death worldwide.Policy of Dealing with Allegations of Research Misconduct.Policy of Screening for Plagiarism Process. ![]() Did you ever notice those wonderful medallions embedded in the ground along Denver’s 17th St., south of Union Station? It’s the Wall Street of the Rockies honor walk, one of Denver’s overlooked treasures. Touch for a list and map of all markers in Denver. This page online Yo Soy Joaquin (a few steps from this marker) Rocky Mountain Fashion (within shouting distance of this marker) Cherry Creek Emigrant's Song (within shouting distance of this marker) The City Beautiful (about 300 feet away, measured in a direct line) Private Profits and the Public Good (about 300 feet away) Coal Miner's Daughter (about 400 feet away) All Washed Up (about 500 feet away). Let the Buyer Beware (here, next to this marker) At least 8 other markers are within walking distance of this marker. Marker is at or near this postal address: 1301 17th Street, Denver CO 80202, United States of America. Marker can be reached from 17th Street just west of Larimer Street, on the right when traveling south. Marker is in Denver, Colorado, in Denver County. A significant historical month for this entry is February 1864. In addition, it is included in the Colorado, Denver, Wall Street of the Rockies series list. This historical marker is listed in these topic lists: Animals His horse had deserted him and Jim was in tears.Įrected by Walk of Fame International. Six days later, the desperado was captured 25 miles south of Colorado City. The gold bars were so heavy that he began dropping them only one mile away in what is now Cheesman Park. The first man to rob the Denver Mint was “Small Bad Jim” – James Clark. It is in Central in Denver in Denver County Colorado ![]() This historical marker was erected by Walk of Fame International. His horse had deserted him and Jim was in tears. ![]() , The first man to rob the Denver Mint was “Small Bad Jim” – James Clark. Data Encryption (iOS)Įncrypt your iOS device’s backup to protect sensitive data from unauthorized access. ![]() getintopc Data Backup (iOS)Ĭreate a full or selective backup of your iOS device data and restore it when needed. Spoof your iOS device’s GPS location to access location-based apps and services from anywhere in the world. Record your iOS device’s screen, including audio, to capture gameplay, app demos, and more. Root your Android device safely to unlock advanced features and customize your device’s functionality. Manage your mobile data efficiently by exporting, importing, deleting, and organizing files, contacts, messages, and more. Safely and permanently erase sensitive data from your device to protect your privacy, ensuring that deleted data cannot be recovered.Įxtract data from iTunes and iCloud backups for iOS devices, even if the device is lost or damaged. Wondershare Dr.Fone is a handy and efficient data recovery application for iPhone, iPad, Android devices and other touch devices. It is full offline installer standalone setup of Wondershare Dr.Fone Free Download for 32/64. Screen Unlock (Android)īypass Android lock screens in various scenarios, such as forgotten passwords, PINs, or pattern locks, without data loss. Wondershare Dr.Fone Free Download Latest Version for Windows. Transfer WhatsApp messages and attachments between devices, backup WhatsApp data, and restore it selectively. Seamlessly transfer data between iOS and Android devices, including contacts, messages, photos, videos, call logs, and more, with just a few clicks. Data Backup and RestoreĬreate backups of your mobile device’s data, including app data, and restore it selectively to the same or another device, making it easy to switch or upgrade your smartphone. getintopcįix common iOS and Android system issues, including black screens, stuck on the Apple logo, boot loop, and other issues without data loss, using the repair feature. It supports various data loss scenarios, including accidental deletion, system crashes, and more. Features of Wondershare Dr.Fone toolkit for iOS and Android Free Download getintopc Data RecoveryĮasily recover lost or deleted data, such as contacts, messages, photos, videos, and more, from both iOS and Android devices. Whether you’ve accidentally lost crucial data, need to manage your device efficiently, or want to transfer data seamlessly between devices, Dr.Fone provides a reliable and intuitive platform to address your mobile needs, making it an essential tool for smartphone users. Wondershare Dr.Fone toolkit for iOS and Android Free Download getintopc toolkit is a comprehensive and user-friendly software solution designed for both iOS and Android devices, offering a one-stop toolkit for data recovery, device management, data transfer, and more. Features of Wondershare Dr.Fone toolkit for iOS and Android Free Download getintopc.Tap "Grant" and when you see a "Success" message, the device has been successfully rooted. A good example is "Greenify" or "Titanium Backup" When attempting to use one of these apps, a popup should appear requesting Superuser access. You can test the success of the rooting procedure by installing an app that requires root access. That completes the process, and you should now see the SuperSU app on your device. Tap "Wipe cache/Dalvik" when SuperSU is installed, and then select the "Reboot System" to continue your operation. Step 4: The duration of installing the SuperSU zip file in TWRP recovery mode depends on actual situations, so please be patient. Select it and then "Swipe to confirm flash." Step 3: You should see the option to install the SuperSU zip file you downloaded. On the TWRP recovery screen, tap "Install" to begin the process. For your specific device, find the proper button combination by searching for "TWRP (Device Model name)" in Google. These buttons you have to hold down vary from one device to another. To do that, you will need to hold down specific buttons on your device. Step 2: Get the device in the TWRP recovery environment. It also supports parts of Xiaomi, Redmi, OPPO, Realme, and Vivo devices. Remove Google FRP Lock: Android 6/7/8/9/10/11/12 for Samsung series devices. ![]() ![]() If you download it on your computer, you need to transfer it to your device. Unlock Android Screen: Android 2.1 and up to the latest, including most Google, Sony, Motorola, LG, HTC, Huawei, Xiaomi etc Android phones. Step 1: On your phone or computer browser, go to the SuperSU Root site and download the SuperSU zip file. See the following simple steps to learn the details: Once the TWRP recovery environment is installed on your device, you are ready to Flash SuperSU and gain root access. Go to the TWRP site to download the right one for your device. ![]() To use SuperSU, you first need to install the TWRP recovery environment on your device. ![]()
![]() ![]() “I’m just thinking about my job, trying to do the best that I could do,” Brady said. The former Bucs receiver recently got turned down for getting $2 million in performance incentives guaranteed according to ESPN’s Jenna Laine.īrady also dodged a question about Brown’s ankle. “Just part of playing football, playing quarterback.”īrown had five targets in the game before his exit as he finished with three catches for 26 yards. “You realize that guys are going to be open and unfortunately, you don’t get it sometimes and other times, you make bad reads, and you make bad throws,” Brady added. Try to read the coverage and try to find the open guy.” “As a quarterback, you just obviously do the best you could do. ![]() “You want to get everybody involved obviously, and I think the receiver position … they’re a long ways from the football when you stand out there,” Brady said. The latest Bucs news straight to your inbox! Join the Heavy on Bucs newsletter here!īrady didn’t take the bait directly when asked about Brown not getting enough targets, which Arians said was the issue during the Jan. Given Brady’s candidness in his documentary, “ Man in the Arena“, he could talk about what transpired with Brown someday in a similar setting. Brown also posted a text thread with Brady’s trainer, Alex Guerrero, and claimed Guerrero owes him $50,000 for work not done.īrady, who played a significant role in Brown joining the Bucs in 2020, deflected questions about Brown’s actions throughout the media session. The Bucs kept Brown on the roster until Thursday morning before his release amid Brown’s recent posts of text conversations with Arians about the ankle injury. Brown then publicly claimed Arians forced him to play despite an ankle injury that caused “extreme” pain. During the Bucs’ 28-24 win over the New York Jets on Sunday, January 2, Brown ripped off his jersey, tossed gear into the stands and ran out of the stadium after a heated conversation with head coach Bruce Arians. He eventually settled the debt, but he called out the media for pushing the story.Brown’s sideline outburst and exit followed by a social media storm this week became the latest thing for the Bucs to deal with. The former Patriots wide receiver has had quite the drama-filled season, as his former personal chef came forward with allegations that Brown, who did not pay him, was using a fake vaccination card. He was benched after reportedly throwing a ball at Ben Roethlisberger while with the Pittsburgh Steelers in 2018 before he was traded, and the Las Vegas Raiders fined and released him before he played a game in 2019. While his latest antics certainly are his most dramatic exit, this certainly isn’t the first instance of Brown having trouble in the middle of the season. I think everyone should be very compassionate and empathetic toward some very difficult things that are happening.” The most important thing about football are the relationships with your friends and your teammates. “We have a lot of friendships that will last. We want to see him be at his best and unfortunately it won’t be with our team. ![]() “I think we all want him to just, I think everybody should find, do what they can to help him in ways that he really needs it. “Yeah, that’s obviously a difficult situation,” Brady said. Sox Transactions, Trades, and Free Agents.Tom Brady Reacts To Antonio Brown's Outburst, Release By Buccaneers |
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